Research and Development
In the field of Medically assisted procreation (Map), the Research and Development (R&D) sector of IVF red S.r.l. plays a key role in the improvement of existing techniques and in the development of new methodologies, aimed at guaranteeing increasingly safe and effective treatments to couples facing fertility problems. R&D in this sector encompasses various scientific and technological fields. Here are some of the main aspects and areas of interest:
In vitro Folliculogenesis
- In vitro folliculogenesis is the process that involves the activation and development of ovarian follicles cultivated outside the organism, starting from strips of cortical ovarian tissue.
- In the context of assisted reproduction, the goal of in vitro folliculogenesis is to activate primordial follicles and, through specific culture systems, bring them to full maturation.
- Ovarian tissue culture can take place in both static and dynamic conditions. In either case, it is essential to accurately replicate the ovarian environment by using growth factors, hormones, and nutrients, which are critical for supporting follicular growth and oocyte maturation.
Cryopreservation
- Vitrification Techniques: Optimization of cryopreservation techniques for oocytes, sperm, and embryos to improve survival rates and maintain cell integrity.
- Ovarian Tissue Preservation: Development of methods to preserve and later transplant ovarian tissue to maintain fertility in patients undergoing cancer treatments.
Studies on Sperm Quality
- Sperm DNA Analysis: Research on sperm DNA fragmentation and its effects on fertility and embryonic development.
- Improvement of Sperm Selection Methods: Development of techniques to select sperm with the highest fertilization potential and support for embryonic development.
Improvement of In Vitro Fertilization (IVF) Techniques
- Optimization of Ovarian Stimulation Protocols: In collaboration with gynecologists affiliated with IVF RED centers, the development of new protocols to enhance ovarian response, reduce side effects, and increase the number of high-quality oocytes.
- Improvement of Embryo Culture: Research on new culture media and environmental conditions to optimize the development of embryos in vitro.
- Embryo Selection: Utilization of advanced imaging techniques and artificial intelligence algorithms to select embryos with the highest implantation potential.
Innovations in Laboratory Technology
- Micromanipulation and ICSI: Development of advanced micromanipulation techniques to improve intracytoplasmic sperm injection (ICSI) and reduce damage to oocytes.
- Bioprinting: Use of 3D printing to create structures resembling ovarian or testicular tissues for research studies and potentially for future clinical applications.
Microfluidics
- Microfluidic devices for sperm selection: High-quality sperm can be selected using microfluidic devices based on criteria such as motility, morphology, thermotaxis, and chemotaxis.
-Embryo culture systems: Microfluidic devices can create dynamic microenvironments that more closely mimic the natural conditions of the uterus, thereby improving embryo development rates.
Clinical Research and Trials
- Randomized Clinical Trials: Conducting clinical trials to test new therapies, drugs, or assisted reproduction techniques.
- Interdisciplinary Collaboration: Collaboration between research centers, universities, and clinics to share data and results, accelerating innovation.
Research and development in the field of PMA is an ongoing and dynamic process that requires collaboration between researchers, clinicians and laboratory technicians. The ultimate goal is to improve the success rates of PMA treatments, reduce the associated risks and offer increasingly personalized and effective options for patients who wish to have children
How We Work?
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Sampling
Conservation
Analysis
Delivery Result
Appointment
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